A new drug called Jemperli has demonstrated an unprecedented response in a phase two clinical trial, completely eradicating tumors in all 42 patients who participated in the study.
This advance can change the lives of thousands of people, Jemperli had already shown great potential in the fight against cancers with mismatch repair deficiency, which correspond to 5 to 10% of colorectal cancers in the first 24 patients evaluated after the trial. In phase two, all presented a complete and sustained clinical response, with an average of 26.3 months without signs of cancer.
Dr. Andrea Cercek, researcher and oncologist at Memorial Sloan Kettering Cancer Center, highlighted the impact of “this new approach, saying that Jemperli may be a new strategy for the treatment of rectal cancer, leading to complete and lasting regression of the tumor without the need for treatments.” that alter life.”
The new drug emerges as an extremely promising first-line treatment option, avoiding the need for chemotherapy and radiation, this is revolutionary, since traditional treatments are invasive and can significantly affect the quality of life of patients, in addition to having high chance of the cancer metastasizing.
Those who undergo surgeries to treat rectal cancer often suffer long-lasting impacts, including bowel, urinary, and sexual dysfunction, as well as risks of secondary cancers or infertility; Immunotherapy with Jemperli seeks to avoid these debilitating consequences.
Jemperli is a monoclonal antibody that blocks the pd1 receptor, binds to T cells encouraging the immune system to attack cancer cells, last year the FDA approved Jemperli as a complementary treatment for endometrial cancer and now the pharmaceutical company GSK is leading conducted studies for other types of colorectal cancer expecting equally impressive results.
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